2VV4

hPPARgamma Ligand binding domain in complex with 6-oxoOTE

Summary for 2VV4

Entry DOI	10.2210/pdb2vv4/pdb
Related	1FM6 1FM9 1I7I 1K74 1KNU 1NYX 1PRG 1RDT 1WM0 1ZGY 2F4B 2FVJ 2G0G 2G0H 2PRG 2VSR 2VST 2VV0 2VV1 2VV2 2VV3 3PRG 4PRG
Descriptor	PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid, (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid, ... (5 entities in total)
Functional Keywords	receptor, nuclear receptor, ligand binding domain, oxidised fatty acid, transcription factor
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	63533.92
Authors	Itoh, T.,Fairall, L.,Schwabe, J.W.R. (deposition date: 2008-06-02, release date: 2008-08-19, Last modification date: 2023-12-13)
Primary citation	Itoh, T.,Fairall, L.,Amin, K.,Inaba, Y.,Szanto, A.,Balint, B.L.,Nagy, L.,Yamamoto, K.,Schwabe, J.W.R. Structural Basis for the Activation of Pparg by Oxidised Fatty Acids Nat.Struct.Mol.Biol., 15:924-, 2008 Cited by PubMed: 19172745 DOI: 10.1038/NSMB.1474 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation