1NYX
Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist
Summary for 1NYX
Entry DOI | 10.2210/pdb1nyx/pdb |
Related | 1KNU |
Descriptor | peroxisome proliferator activated receptor gamma, (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID (3 entities in total) |
Functional Keywords | ppar, nuclear receptor, transcription, gene regulation, agonist complex |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 63548.69 |
Authors | Ebdrup, S.,Pettersson, I.,Rasmussen, H.B.,Deussen, H.-J.,Frost Jensen, A.,Mortensen, S.B.,Fleckner, J.,Pridal, L.,Nygaard, L.,Sauerberg, P. (deposition date: 2003-02-14, release date: 2003-07-15, Last modification date: 2024-03-13) |
Primary citation | Ebdrup, S.,Pettersson, I.,Rasmussen, H.B.,Deussen, H.-J.,Frost Jensen, A.,Mortensen, S.B.,Fleckner, J.,Pridal, L.,Nygaard, L.,Sauerberg, P. Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar J.MED.CHEM., 46:1306-1317, 2003 Cited by PubMed: 12672231DOI: 10.1021/jm021027r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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