2VV0

hPPARgamma Ligand binding domain in complex with DHA

Summary for 2VV0

Related2FVJ 1FM9 2PRG 1KNU 1RDT 1I7I 3PRG 1K74 1FM6 1ZGY 1PRG 2F4B 2VST 2G0H 2VSR 1WM0 4PRG 2G0G 1NYX 2VV3 2VV1 2VV2 2VV4
DescriptorPEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID (3 entities in total)
Functional Keywordsnuclear receptor, transcription regulation, alternative splicing, ligand binding domain, diabetes mellitus, zinc-finger, dna-binding, polymorphism, transcription, zinc, obesity, nucleus, receptor, activator, oxidised fatty acid, transcription factor, metal-binding, phosphoprotein, disease mutation
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight63556.02
Authors
Itoh, T.,Fairall, L.,Schwabe, J.W.R. (deposition date: 2008-06-02, release date: 2008-08-19, Last modification date: 2019-05-08)
Primary citation
Itoh, T.,Fairall, L.,Amin, K.,Inaba, Y.,Szanto, A.,Balint, B.L.,Nagy, L.,Yamamoto, K.,Schwabe, J.W.R.
Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15:924-, 2008
PubMed: 19172745 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.1474
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.55 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26620 0.2% 6.6% 4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report