2VV2

hPPARgamma Ligand binding domain in complex with 5-HEPA

Summary for 2VV2

Related2FVJ 1FM9 2PRG 1KNU 1RDT 1I7I 3PRG 1K74 1FM6 1ZGY 1PRG 2F4B 2VST 2G0H 2VSR 1WM0 4PRG 2G0G 1NYX 2VV0 2VV1 2VV3 2VV4
DescriptorPEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid (3 entities in total)
Functional Keywordstranscription regulation, alternative splicing, ligand binding domain, nuclear receptor, diabetes mellitus, zinc-finger, dna-binding, polymorphism, transcription, zinc, obesity, nucleus, receptor, activator, oxidised fatty acid, transcription factor, metal-binding, phosphoprotein, disease mutation
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight63854.39
Authors
Itoh, T.,Fairall, L.,Schwabe, J.W.R. (deposition date: 2008-06-02, release date: 2008-08-19, Last modification date: 2019-05-08)
Primary citation
Itoh, T.,Fairall, L.,Amin, K.,Inaba, Y.,Szanto, A.,Balint, B.L.,Nagy, L.,Yamamoto, K.,Schwabe, J.W.R.
Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15:924-, 2008
PubMed: 19172745 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.1474
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.75 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26618 0.2% 6.5% 2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report