1RDT

Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer

Summary for 1RDT

Related1FM9 1FM6
DescriptorRetinoic acid receptor RXR-alpha, LxxLL motif coactivator, Peroxisome proliferator activated receptor gamma, ... (7 entities in total)
Functional Keywordshormone, receptor, polymorphism, hormone-growth factor complex, hormone/growth factor
Biological sourceHomo sapiens (human)
Cellular locationNucleus P19793 P37231
Total number of polymer chains4
Total molecular weight65772.22
Authors
Haffner, C.D.,Lenhard, J.M.,Miller, A.B.,McDougald, D.L.,Dwornik, K.,Ittoop, O.R.,Gampe Jr., R.T.,Xu, H.E.,Blanchard, S.,Montana, V.G. (deposition date: 2003-11-06, release date: 2004-11-09, Last modification date: 2011-07-13)
Primary citation
Haffner, C.D.,Lenhard, J.M.,Miller, A.B.,McDougald, D.L.,Dwornik, K.,Ittoop, O.R.,Gampe Jr., R.T.,Xu, H.E.,Blanchard, S.,Montana, V.G.,Consler, T.G.,Bledsoe, R.K.,Ayscue, A.,Croom, D.
Structure-based design of potent retinoid X receptor alpha agonists.
J.Med.Chem., 47:2010-2029, 2004
PubMed: 15056000 (PDB entries with the same primary citation)
DOI: 10.1021/jm030565g
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
NMR Information
?

Structure validation

ClashscoreRamachandran outliersSidechain outliers131.9%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report