1RDT
Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 242 | 27114.5 | 1 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (human) | RXRalpha |
| 2 | B (B) | LxxLL motif coactivator | polymer | 25 | 2806.2 | 1 | Pfam (PF08832) UniProt (by SIFTS) (Q15788) | ||
| 3 | C (D) | Peroxisome proliferator activated receptor gamma | polymer | 284 | 32557.8 | 1 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma |
| 4 | D (E) | LxxLL motif coactivator | polymer | 23 | 2368.6 | 1 | UniProt (by SIFTS) (Q92793) | ||
| 5 | E (A) | (S)-(2E)-3[4-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL)TETRAHYDRO-1-BENZOFURAN-2-YL]-2-PROPENOIC ACID | non-polymer | 378.5 | 1 | Chemie (L79) | |||
| 6 | F (D) | 2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID | non-polymer | 546.6 | 1 | Chemie (570) | |||
| 7 | G, H, I, J (A, B, D, E) | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A: 225 - 462 (UniProt: P19793)
D: 207 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Met 221 | - | cloning artifact |
| Lys 222 | - | cloning artifact |
| Lys 223 | - | cloning artifact |
| Gly 224 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Met 194 | - | cloning artifact |
| Lys 195 | - | cloning artifact |
| Lys 196 | - | cloning artifact |
| Gly 197 | - | cloning artifact |
| His 198 | - | cloning artifact |
| His 199 | - | cloning artifact |
| His 200 | - | cloning artifact |
| His 201 | - | cloning artifact |
| His 202 | - | cloning artifact |
| His 203 | - | cloning artifact |
| Gly 204 | - | cloning artifact |
| Arg 205 | - | cloning artifact |
| Ala 206 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64847.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 925.1 | |
| All* | Total formula weight | 65772.2 |
