2G0H

Structure-based drug design of a novel family of PPAR partial agonists: virtual screening, x-ray crystallography and in vitro/in vivo biological activities

Summary for 2G0H

• Entry DOI: 10.2210/pdb2g0h/pdb
• Related: 2G0G
• Descriptor: Peroxisome proliferator-activated receptor gamma, N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]-3,5-BIS(TRIFLUOROMETHYL)BENZENESULFONAMIDE (3 entities in total)
• Functional Keywords: ppar, transcription activator
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q86U60
• Total number of polymer chains: 2
• Total formula weight: 63064.96

Authors

Lu, I.L.,Peng, Y.H.,Huang, C.F.,Lin, Y.T.,Hsu, J.T.A.,Wu, S.Y. (deposition date: 2006-02-13, release date: 2006-05-16, Last modification date: 2023-10-25)

• Primary citation: Lu, I.L.,Huang, C.F.,Peng, Y.H.,Lin, Y.T.,Hsieh, H.P.,Chen, C.T.,Lien, T.W.,Lee, H.J.,Mahindroo, N.,Prakash, E.,Yueh, A.,Chen, H.Y.,Goparaju, C.M.,Chen, X.,Liao, C.C.,Chao, Y.S.,Hsu, J.T.,Wu, S.Y.; Structure-Based Drug Design of a Novel Family of PPARgamma Partial Agonists: Virtual Screening, X-ray Crystallography, and in Vitro/in Vivo Biological Activities; J.Med.Chem., 49:2703-2712, 2006; PubMed: 16640330; DOI: 10.1021/jm051129s

Experimental method

X-RAY DIFFRACTION (2.3 Å)