1I7I

CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST AZ 242

Summary for 1I7I

Related1I7G
DescriptorPEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, (2S)-2-ETHOXY-3-[4-(2-{4-[(METHYLSULFONYL)OXY]PHENYL}ETHOXY)PHENYL]PROPANOIC ACID (3 entities in total)
Functional Keywordsanti parallel helix sandwich, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight67235.7
Authors
Petersen, J.F.W.,Cronet, P.,Folmer, R.,Blomberg, N.,Sjoblom, K.,Karlsson, U.,Lindstedt, E.-L.,Bamberg, K. (deposition date: 2001-03-09, release date: 2002-03-09, Last modification date: 2011-07-13)
Primary citation
Cronet, P.,Petersen, J.F.,Folmer, R.,Blomberg, N.,Sjoblom, K.,Karlsson, U.,Lindstedt, E.L.,Bamberg, K.
Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.
Structure, 9:699-701, 2001
PubMed: 11587644 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(01)00634-7
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.35 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers162.6%5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report