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1I7I

CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST AZ 242

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE AZ2 A 101
ChainResidue
APHE282
ATYR473
AGLY284
ACYS285
ASER289
AHIS323
AMET348
AMET364
AHIS449
ALEU469

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE AZ2 B 478
ChainResidue
BPHE264
BHIS266
BILE281
BPHE282
BGLY284
BCYS285
BSER289
BHIS323
BILE341
BMET348
BMET364
BHIS449

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
AGLN286
AHIS323
AHIS449
ATYR473
BGLN286
BHIS323
BHIS449
BTYR473

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
BLYS224

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PDB entries from 2024-11-06

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