1I7G
CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN FROM HUMAN PPAR-ALPHA IN COMPLEX WITH THE AGONIST AZ 242
Summary for 1I7G
Entry DOI | 10.2210/pdb1i7g/pdb |
Related | 1I7I |
Descriptor | PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA, SODIUM ION, (2S)-2-ETHOXY-3-[4-(2-{4-[(METHYLSULFONYL)OXY]PHENYL}ETHOXY)PHENYL]PROPANOIC ACID, ... (5 entities in total) |
Functional Keywords | anti parallel helix sandwich, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q07869 |
Total number of polymer chains | 1 |
Total formula weight | 33630.86 |
Authors | Petersen, J.F.W.,Cronet, P.,Folmer, R.,Blomberg, N.,Sjoblom, K.,Karlsson, U.,Lindstedt, E.-L.,Bamberg, K. (deposition date: 2001-03-09, release date: 2002-03-09, Last modification date: 2023-08-09) |
Primary citation | Cronet, P.,Petersen, J.F.,Folmer, R.,Blomberg, N.,Sjoblom, K.,Karlsson, U.,Lindstedt, E.L.,Bamberg, K. Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family. Structure, 9:699-706, 2001 Cited by PubMed Abstract: The peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors belonging to the nuclear receptor family. The roles of PPARalpha in fatty acid oxidation and PPARgamma in adipocyte differentiation and lipid storage have been characterized extensively. PPARs are activated by fatty acids and eicosanoids and are also targets for antidyslipidemic drugs, but the molecular interactions governing ligand selectivity for specific subtypes are unclear due to the lack of a PPARalpha ligand binding domain structure. PubMed: 11587644DOI: 10.1016/S0969-2126(01)00634-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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