2XKW

LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST PIOGLITAZONE

Summary for 2XKW

Related2FVJ 2VV2 1FM9 2VV0 2VV1 1KNU 2PRG 1RDT 3PRG 1I7I 2VV4 1K74 1FM6 1PRG 1ZGY 2F4B 2VST 2G0H 2VSR 1WM0 4PRG 2G0G 2VV3 1NYX 2YFE
DescriptorPEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA, (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ... (5 entities in total)
Functional Keywordstranscription, nuclear receptor, transcription factor, gene regulation, thiazolidinedione
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total molecular weight63948.41
Authors
Mueller, J.J.,Schupp, M.,Unger, T.,Kintscher, U.,Heinemann, U. (deposition date: 2010-07-14, release date: 2011-08-10, Last modification date: 2019-05-08)
Primary citation
Mueller, J.J.,Schupp, M.,Unger, T.,Kintscher, U.,Heinemann, U.
Binding Diversity of Pioglitazone by Peroxisome Proliferator-Activated Receptor-Gamma
To be Published,
Experimental method
X-RAY DIFFRACTION (2.02 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2103 0.6% 3.7% 6.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report