1RV1
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CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Lukacs, C., Kammlott, U., Graves, B.
Deposit date:2003-12-12
Release date:2004-01-20
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Science, 303, 2004
1T4E
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STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH A BENZODIAZEPINE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Grasberger, B.L., Schubert, C., Koblish, H.K., Carver, T.E., Franks, C.F., Zhao, S.Y., Lu, T., LaFrance, L.V., Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1T4F
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STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH AN OPTIMIZED P53 PEPTIDE
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-), optimized p53 peptide
Authors:Grasberger, B.L., Schubert, C., Koblish, H.K., Carver, T.E., Franks, C.F., Zhao, S.Y., Lu, T., LaFrance, L.V., Parks, D.J.
Deposit date:2004-04-29
Release date:2005-02-08
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
J.Med.Chem., 48, 2005
1TTV
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NMR STRUCTURE OF A COMPLEX BETWEEN MDM2 AND A SMALL MOLECULE INHIBITOR
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Fry, D.C., Emerson, S.D., Palme, S., Vu, B.T., Liu, C.M., Podlaski, F.
Deposit date:2004-06-23
Release date:2005-01-04
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:NMR structure of a complex between MDM2 and a small molecule inhibitor.
J.Biomol.Nmr, 30, 2004
1UHR
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SOLUTION STRUCTURE OF THE SWIB DOMAIN OF MOUSE BRG1-ASSOCIATED FACTOR 60A
Descriptor:SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily D member 1
Authors:Yamada, K., Saito, K., Nameki, N., Inoue, M., Koshiba, S., Shirouzu, M., Terada, T., Yabuki, T., Aoki, M., Matsuda, T., Seki, E., Hirota, H., Yoshida, M., Tanaka, A., Osanai, T., Arakawa, T., Carninci, P., Kawai, J., Hayashizaki, Y., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-07-09
Release date:2004-08-24
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the SWIB domain of mouse BRG1-associated factor 60a
To be Published
1V31
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SOLUTION STRUCTURE OF THE SWIB/MDM2 DOMAIN OF THE HYPOTHETICAL PROTEIN AT5G14170 FROM ARABIDOPSIS THALIANA
Descriptor:hypothetical protein RAFL11-05-P19
Authors:Yoneyama, M., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-21
Release date:2004-04-21
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g14170 from Arabidopsis thaliana
To be Published
1V32
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SOLUTION STRUCTURE OF THE SWIB/MDM2 DOMAIN OF THE HYPOTHETICAL PROTEIN AT5G08430 FROM ARABIDOPSIS THALIANA
Descriptor:hypothetical protein RAFL09-47-K03
Authors:Yoneyama, M., Tochio, N., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2003-10-24
Release date:2004-04-24
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Solution structure of the SWIB/MDM2 domain of the hypothetical protein At5g08430 from Arabidopsis thaliana
To be Published
1YCQ
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XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53
Descriptor:MDM2, P53
Authors:Kussie, P.H., Pavletich, N.P.
Deposit date:1996-09-30
Release date:1997-11-19
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Science, 274, 1996
1YCR
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MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF P53
Descriptor:MDM2, P53
Authors:Kussie, P.H., Pavletich, N.P.
Deposit date:1996-09-30
Release date:1997-11-19
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
Science, 274, 1996
1Z1M
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NMR STRUCTURE OF UNLIGANDED MDM2
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Uhrinova, S., Uhrin, D., Powers, H., Watt, K., Zheleva, D., Fischer, P., McInnes, C., Barlow, P.N.
Deposit date:2005-03-04
Release date:2005-06-28
Last modified:2009-02-24
Method:SOLUTION NMR
Cite:Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding
J.Mol.Biol., 350, 2005
2AXI
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HDM2 IN COMPLEX WITH A BETA-HAIRPIN
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-), cyclic 8-mer peptide
Authors:Mittl, P.R.E., Fasan, R., Robinson, J., Gruetter, M.G.
Deposit date:2005-09-05
Release date:2006-03-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction.
Chembiochem, 7, 2006
2GV2
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MDM2 IN COMPLEX WITH AN 8-MER P53 PEPTIDE ANALOGUE
Descriptor:Ubiquitin-protein ligase E3 Mdm2 (E.C.6.3.2.-)
Authors:Schubert, C., Sakurai, K.
Deposit date:2006-05-02
Release date:2006-09-05
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2.
J.Am.Chem.Soc., 128, 2006
2LZG
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NMR STRUCTURE OF MDM2 (6-125) WITH PIP-1
Descriptor:E3 ubiquitin-protein ligase Mdm2
Authors:Michelsen, K.B., Jordan, J.B., Lewis, J., Long, A.M., Yang, E., Rew, Y., Zhou, J., Yakowec, P., Schnier, P.D., Huang, X., Poppe, L.
Deposit date:2012-10-02
Release date:2012-11-07
Method:SOLUTION NMR
Cite:Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
J.Am.Chem.Soc., 134, 2012
2M86
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SOLUTION STRUCTURE OF HDM2 WITH ENGINEERED CYCLOTIDE
Descriptor:MCo-PMI, E3 ubiquitin-protein ligase Mdm2
Authors:Majumder, S., Ji, Y., Millard, M., Borra, R., Bi, T., Elnagar, A.Y., Neamati, N., Camarero, J.A.
Deposit date:2013-05-07
Release date:2013-07-31
Last modified:2013-08-21
Method:SOLUTION NMR
Cite:In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide.
J.Am.Chem.Soc., 135, 2013
2MPS
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STRUCTURE OF COMPLEX OF MDM2(3-109) AND P73 TAD(10-25)
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-), Tumor protein p73
Authors:Shin, J.S., Ha, J.H., Chi, S.W.
Deposit date:2014-06-02
Release date:2015-06-03
Method:SOLUTION NMR
Cite:Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition
Cell Cycle, 14, 2015
2MWY
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MDMX-P53
Descriptor:Protein Mdm4, Cellular tumor antigen p53
Authors:Grace, C.R.
Deposit date:2014-12-03
Release date:2016-01-27
Last modified:2016-05-11
Method:SOLUTION NMR
Cite:Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N06
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MDMX-298
Descriptor:Protein Mdm4
Authors:Grace, C.R., Kriwacki, R.W.
Deposit date:2015-03-04
Release date:2016-01-27
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N0U
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MDMX-057
Descriptor:Protein Mdm4
Authors:Grace, C.R., Kriwacki, R.W.
Deposit date:2015-03-17
Release date:2016-01-27
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N0W
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MDMX-SJ212
Descriptor:Protein Mdm4
Authors:Grace, C.R., Kriwacki, R.W.
Deposit date:2015-03-17
Release date:2016-01-27
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2N14
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MDMX-295
Descriptor:Protein Mdm4
Authors:Grace, C.R., Kriwacki, R.W.
Deposit date:2015-03-20
Release date:2016-01-27
Last modified:2016-05-04
Method:SOLUTION NMR
Cite:Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
J.Mol.Biol., 428, 2016
2RUH
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CHEMICAL SHIFT ASSIGNMENTS FOR MIP AND MDM2 IN BOUND STATE
Descriptor:E3 ubiquitin-protein ligase Mdm2 (E.C.6.3.2.-)
Authors:Nagata, T., Shirakawa, K., Kobayashi, N., Shiheido, H., Horisawa, K., Katahira, M., Doi, N., Yanagawa, H.
Deposit date:2014-06-03
Release date:2014-10-15
Method:SOLUTION NMR
Cite:Structural Basis for Inhibition of the MDM2:p53 Interaction by an Optimized MDM2-Binding Peptide Selected with mRNA Display
Plos One, 9, 2014
2VYR
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STRUCTURE OF HUMAN MDM4 N-TERMINAL DOMAIN BOUND TO A SINGLE DOMAIN ANTIBODY
Descriptor:MDM4 PROTEIN, HUMAN SINGLE DOMAIN ANTIBODY
Authors:Yu, G.W., Vaysburd, M., Allen, M.D., Settanni, G., Fersht, A.R.
Deposit date:2008-07-28
Release date:2008-11-25
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Human Mdm4 N-Terminal Domain Bound to a Single-Domain Antibody.
J.Mol.Biol., 385, 2009
2Z5S
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MOLECULAR BASIS FOR THE INHIBITION OF P53 BY MDMX
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Rothweiler, U., Szwagierczak, A., Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
2Z5T
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MOLECULAR BASIS FOR THE INHIBITION OF P53 BY MDMX
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Rothweiler, U., Szwagierczak, A., Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
3DAB
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STRUCTURE OF THE HUMAN MDMX PROTEIN BOUND TO THE P53 TUMOR SUPPRESSOR TRANSACTIVATION DOMAIN
Descriptor:Mdm4 protein, Cellular tumor antigen p53
Authors:Popowicz, G.M., Czarna, A., Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Last modified:2009-02-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Cell Cycle, 7, 2008
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