7AD0
X-ray structure of Mdm2 with modified p53 peptide
Summary for 7AD0
| Entry DOI | 10.2210/pdb7ad0/pdb |
| Descriptor | E3 ubiquitin-protein ligase Mdm2, Modified p53 peptide (3 entities in total) |
| Functional Keywords | p53, mdm2, mdmx, protein-protein interaction, inhibitor, cancer, ligase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 12 |
| Total formula weight | 73159.56 |
| Authors | Twarda-Clapa, A.,Fortuna, P.,Grudnik, P.,Dubin, G.,Berlicki, L.,Holak, T.A. (deposition date: 2020-09-13, release date: 2020-10-28, Last modification date: 2024-01-31) |
| Primary citation | Fortuna, P.,Twarda-Clapa, A.,Skalniak, L.,Ozga, K.,Holak, T.A.,Berlicki, L. Systematic ""foldamerization"" of peptide inhibiting p53-MDM2/X interactions by the incorporation of trans- or cis-2-aminocyclopentanecarboxylic acid residues Eur.J.Med.Chem., 208:112814-, 2020 Cited by DOI: 10.1016/j.ejmech.2020.112814PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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