6T2E
Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions
Summary for 6T2E
Entry DOI | 10.2210/pdb6t2e/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, Stapled peptide GAR300-Gm (3 entities in total) |
Functional Keywords | inhibitor, complex, mdm2, stapled peptides, ugi mcr-based macrocyclizations, peptide binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 11848.83 |
Authors | Groves, R.M.,Ali, M.A.,Atmaj, J.,van Oosterwijk, N.,Domling, A.,Rivera, G.D.,Ricardo, G.M. (deposition date: 2019-10-08, release date: 2020-01-29, Last modification date: 2024-01-24) |
Primary citation | Ricardo, M.G.,Ali, A.M.,Plewka, J.,Surmiak, E.,Labuzek, B.,Neochoritis, C.G.,Atmaj, J.,Skalniak, L.,Zhang, R.,Holak, T.A.,Groves, M.,Rivera, D.G.,Domling, A. Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 59:5235-5241, 2020 Cited by PubMed: 31944488DOI: 10.1002/anie.201916257 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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