6T2D

Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions

Summary for 6T2D

• Entry DOI: 10.2210/pdb6t2d/pdb
• Descriptor: E3 ubiquitin-protein ligase Mdm2, Stapled peptide GAR300-Gp, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (6 entities in total)
• Functional Keywords: inhibitor, complex, mdm2, stapled peptides, ugi mcr-based macrocyclizations, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 12443.62

Authors

Groves, R.M.,Ali, M.A.,Atmaj, J.,van Oosterwijk, N.,Domling, A.,Rivera, G.D.,Ricardo, G.M. (deposition date: 2019-10-08, release date: 2020-01-29, Last modification date: 2024-01-24)

• Primary citation: Ricardo, M.G.,Ali, A.M.,Plewka, J.,Surmiak, E.,Labuzek, B.,Neochoritis, C.G.,Atmaj, J.,Skalniak, L.,Zhang, R.,Holak, T.A.,Groves, M.,Rivera, D.G.,Domling, A.; Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions.; Angew.Chem.Int.Ed.Engl., 59:5235-5241, 2020; PubMed: 31944488; DOI: 10.1002/anie.201916257

Experimental method

X-RAY DIFFRACTION (1.8 Å)