6HFA
Crystal structure of hDM2 in complex with a C-terminal triurea capped peptide chimera foldamer.
Summary for 6HFA
Entry DOI | 10.2210/pdb6hfa/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, LM266, 1-[(2~{S})-2-azanyl-3-methyl-butyl]urea (3 entities in total) |
Functional Keywords | protein foldamer complex, protein protein interaction inhibitor, urea based chimera foldamer, oncoprotein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 25253.41 |
Authors | Buratto, J.,Mauran, L.,Goudreau, S.,Fribourg, S.,Guichard, G. (deposition date: 2018-08-21, release date: 2020-07-08, Last modification date: 2023-11-15) |
Primary citation | Cussol, L.,Mauran-Ambrosino, L.,Buratto, J.,Belorusova, A.Y.,Neuville, M.,Osz, J.,Fribourg, S.,Fremaux, J.,Dolain, C.,Goudreau, S.R.,Rochel, N.,Guichard, G. Structural Basis for alpha-Helix Mimicry and Inhibition of Protein-Protein Interactions with Oligourea Foldamers. Angew.Chem.Int.Ed.Engl., 2020 Cited by PubMed: 32935897DOI: 10.1002/anie.202008992 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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