6HFA
Crystal structure of hDM2 in complex with a C-terminal triurea capped peptide chimera foldamer.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase Mdm2 | polymer | 98 | 11397.3 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | C, D (C, D) | LM266, 1-[(2~{S})-2-azanyl-3-methyl-butyl]urea | polymer | 11 | 1229.4 | 2 | synthetic construct | ||
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 14 | - | expression tag |
| His 15 | - | expression tag |
| Met 16 | - | expression tag |
| Ala 88 | Val 94 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 25253.4 | |
| All* | Total formula weight | 25253.4 |
