4DIJ
The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction
Summary for 4DIJ
Entry DOI | 10.2210/pdb4dij/pdb |
Related | 1YCR |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide (3 entities in total) |
Functional Keywords | ppi with p53, ppi inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 2 |
Total formula weight | 23493.02 |
Authors | Kallen, J. (deposition date: 2012-01-31, release date: 2012-05-02, Last modification date: 2024-04-03) |
Primary citation | Furet, P.,Chene, P.,De Pover, A.,Valat, T.S.,Lisztwan, J.H.,Kallen, J.,Masuya, K. The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction. Bioorg.Med.Chem.Lett., 22:3498-3502, 2012 Cited by PubMed: 22507962DOI: 10.1016/j.bmcl.2012.03.083 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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