4DIJ
The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | E3 ubiquitin-protein ligase Mdm2 | polymer | 96 | 11172.0 | 2 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | A, B | 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide | non-polymer | 574.5 | 2 | Chemie (BLF) | |||
| 3 | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Glu 33 | Leu 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22344.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1149.0 | |
| All* | Total formula weight | 23493.0 |
