4DIJ
The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE BLF A 201 |
| Chain | Residue |
| A | LEU54 |
| B | MET62 |
| B | TYR67 |
| B | GLN72 |
| B | BLF201 |
| B | HOH319 |
| A | PHE55 |
| A | GLY58 |
| A | ILE61 |
| A | VAL93 |
| A | HIS96 |
| A | ILE99 |
| A | HOH304 |
| A | HOH326 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE BLF B 201 |
| Chain | Residue |
| A | MET62 |
| A | TYR67 |
| A | GLN72 |
| A | BLF201 |
| A | HOH314 |
| B | LEU54 |
| B | GLY58 |
| B | ILE61 |
| B | VAL93 |
| B | HIS96 |
| B | HOH310 |
