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4DIJ

The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
B0005634cellular_componentnucleus
B0043066biological_processnegative regulation of apoptotic process
B0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE BLF A 201
ChainResidue
ALEU54
BMET62
BTYR67
BGLN72
BBLF201
BHOH319
APHE55
AGLY58
AILE61
AVAL93
AHIS96
AILE99
AHOH304
AHOH326

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE BLF B 201
ChainResidue
AMET62
ATYR67
AGLN72
ABLF201
AHOH314
BLEU54
BGLY58
BILE61
BVAL93
BHIS96
BHOH310

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues166
DetailsDomain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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