1RV1

CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR

Summary for 1RV1
Related1YCR
DescriptorUbiquitin-protein ligase E3 Mdm2, CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE (3 entities in total)
Functional Keywordsmdm2, p53, protein-protein interaction, ligase
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains3
Total formula weight33614.70
Authors
Lukacs, C.,Kammlott, U.,Graves, B. (deposition date: 2003-12-12, release date: 2004-01-20, Last modification date: 2011-07-13)
Primary citationCarvajal, D.,Filipovic, Z.,Fotouhi, N.,Graves, B.,Kammlott, U.,Klein, C.,Kong, N.,Liu, E.A.,Lukacs, C.,Podlaski, F.,Vassilev, L.T.,Vu, B.T.
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Science, 303:844-848, 2004
PubMed: 14704432
DOI: 110.1126/science.1092472
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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PDB entries from 2021-06-16