1RV1

CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR

Summary for 1RV1

Entry DOI	10.2210/pdb1rv1/pdb
Related	1YCR
Descriptor	Ubiquitin-protein ligase E3 Mdm2, CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE (3 entities in total)
Functional Keywords	mdm2, p53, protein-protein interaction, ligase
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	3
Total formula weight	33614.70
Authors	Lukacs, C.,Kammlott, U.,Graves, B. (deposition date: 2003-12-12, release date: 2004-01-20, Last modification date: 2023-08-23)
Primary citation	Vassilev, L.T.,Vu, B.T.,Graves, B.,Carvajal, D.,Podlaski, F.,Filipovic, Z.,Kong, N.,Kammlott, U.,Lukacs, C.,Klein, C.,Fotouhi, N.,Liu, E.A. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science, 303:844-848, 2004 Cited by PubMed: 14704432 DOI: 10.1126/science.1092472 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation