1RV1
CRYSTAL STRUCTURE OF HUMAN MDM2 WITH AN IMIDAZOLINE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Ubiquitin-protein ligase E3 Mdm2 | polymer | 85 | 10060.8 | 3 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | p53-binding protein Mdm2, Oncoprotein Mdm2, Double minute 2 protein, Hdm2 |
| 2 | D, E, F, G, H (A, B, C) | CIS-[4,5-BIS-(4-BROMOPHENYL)-2-(2-ETHOXY-4-METHOXYPHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]METHANONE | non-polymer | 686.4 | 5 | Chemie (IMZ) | |||
| 3 | I, J, K (A, B, C) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A, B, C: 25 - 109 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Glu 33 | Leu 33 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 30182.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 3432.2 | |
| All* | Total formula weight | 33614.7 |
