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4ERF

crystal structure of MDM2 (17-111) in complex with compound 29 (AM-8553)

Summary for 4ERF
Entry DOI10.2210/pdb4erf/pdb
Related4ERE
DescriptorE3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl}acetic acid (3 entities in total)
Functional Keywordsmdm2, p53, protein protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains3
Total formula weight34903.38
Authors
Huang, X. (deposition date: 2012-04-20, release date: 2012-05-23, Last modification date: 2024-02-28)
Primary citationRew, Y.,Sun, D.,Gonzalez-Lopez De Turiso, F.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Deignan, J.,Fox, B.M.,Gustin, D.,Huang, X.,Jiang, M.,Jiao, X.,Jin, L.,Kayser, F.,Kopecky, D.J.,Li, Y.,Lo, M.C.,Long, A.M.,Michelsen, K.,Oliner, J.D.,Osgood, T.,Ragains, M.,Saiki, A.Y.,Schneider, S.,Toteva, M.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Medina, J.C.,Olson, S.H.
Structure-based design of novel inhibitors of the MDM2-p53 interaction.
J.Med.Chem., 55:4936-4954, 2012
Cited by
PubMed: 22524527
DOI: 10.1021/jm300354j
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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