4ERE

crystal structure of MDM2 (17-111) in complex with compound 23

Summary for 4ERE

• Entry DOI: 10.2210/pdb4ere/pdb
• Related: 4ERF
• Descriptor: E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-1-[(2S)-1-tert-butoxy-1-oxobutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]acetic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: mdm2, p53, protein-protein interaction, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 2
• Total formula weight: 23449.06

Authors

Huang, X. (deposition date: 2012-04-20, release date: 2012-05-23, Last modification date: 2024-02-28)

• Primary citation: Rew, Y.,Sun, D.,Gonzalez-Lopez De Turiso, F.,Bartberger, M.D.,Beck, H.P.,Canon, J.,Chen, A.,Chow, D.,Deignan, J.,Fox, B.M.,Gustin, D.,Huang, X.,Jiang, M.,Jiao, X.,Jin, L.,Kayser, F.,Kopecky, D.J.,Li, Y.,Lo, M.C.,Long, A.M.,Michelsen, K.,Oliner, J.D.,Osgood, T.,Ragains, M.,Saiki, A.Y.,Schneider, S.,Toteva, M.,Yakowec, P.,Yan, X.,Ye, Q.,Yu, D.,Zhao, X.,Zhou, J.,Medina, J.C.,Olson, S.H.; Structure-based design of novel inhibitors of the MDM2-p53 interaction.; J.Med.Chem., 55:4936-4954, 2012; PubMed: 22524527; DOI: 10.1021/jm300354j

Experimental method

X-RAY DIFFRACTION (1.8 Å)