4ERE
crystal structure of MDM2 (17-111) in complex with compound 23
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 0R2 A 201 |
| Chain | Residue |
| A | LEU54 |
| B | HIS96 |
| B | 0R2201 |
| B | HOH334 |
| A | ILE61 |
| A | VAL93 |
| A | LYS94 |
| A | HIS96 |
| A | ILE99 |
| A | HOH323 |
| A | HOH363 |
| B | PHE55 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 202 |
| Chain | Residue |
| A | HIS96 |
| A | HOH313 |
| B | LYS39 |
| B | LYS94 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 0R2 B 201 |
| Chain | Residue |
| A | PHE55 |
| A | HIS96 |
| A | 0R2201 |
| A | HOH339 |
| A | HOH363 |
| B | LYS51 |
| B | LEU54 |
| B | ILE61 |
| B | VAL93 |
| B | LYS94 |
| B | HIS96 |
| B | HOH327 |
