4ERF
crystal structure of MDM2 (17-111) in complex with compound 29 (AM-8553)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, C, E) | E3 ubiquitin-protein ligase Mdm2 | polymer | 96 | 11156.1 | 3 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | D, E, F (A, C, E) | {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl}acetic acid | non-polymer | 478.4 | 3 | Chemie (0R3) PubChem (58573850) PubChem (67999739) PubChem (56965957) PubChem (58573878) PubChem (67999304) PubChem (67999323) PubChem (67999325) PubChem (67999611) PubChem (68000476) PubChem (138626017) PubChem (138641737) PubChem (156490328) PubChem (118422579) PubChem (118422580) PubChem (118422582) PubChem (121336908) PubChem (122692899) PubChem (124084801) PubChem (125344139) PubChem (129152677) PubChem (130227367) PubChem (135210354) PubChem (137704638) PubChem (139305597) PubChem (154473367) PubChem (155317424) PubChem (164138355) | |||
| 3 | G, H, I (A, C, E) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A, C, E: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33468.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1435.2 | |
| All* | Total formula weight | 34903.4 |
