5OAI

Structure of MDM2 with low molecular weight inhibitor

Summary for 5OAI

Entry DOI	10.2210/pdb5oai/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, 3-[(1~{R})-2-(~{tert}-butylamino)-1-[methanoyl-[[3,4,5-tris(fluoranyl)phenyl]methyl]amino]-2-oxidanylidene-ethyl]-6-chloranyl-1~{H}-indole-2-carboxylic acid (3 entities in total)
Functional Keywords	p53, mdm2, mdmx, protein-protein interaction, cancer, inhibitor, ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	11895.25
Authors	Twarda-Clapa, A.,Neochoritis, C.G.,Grudnik, P.,Dubin, G.,Domling, A.,Holak, T.A. (deposition date: 2017-06-22, release date: 2019-02-13, Last modification date: 2024-01-17)
Primary citation	Skalniak, L.,Twarda-Clapa, A.,Neochoritis, C.G.,Surmiak, E.,Machula, M.,Wisniewska, A.,Labuzek, B.,Ali, A.M.,Krzanik, S.,Dubin, G.,Groves, M.,Domling, A.,Holak, T.A. A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wtosteosarcoma cells. Febs J., 286:1360-1374, 2019 Cited by PubMed: 30715803 DOI: 10.1111/febs.14774 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation