5OAI
Structure of MDM2 with low molecular weight inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | E3 ubiquitin-protein ligase Mdm2 | polymer | 97 | 11399.4 | 1 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
2 | A | 3-[(1~{R})-2-(~{tert}-butylamino)-1-[methanoyl-[[3,4,5-tris(fluoranyl)phenyl]methyl]amino]-2-oxidanylidene-ethyl]-6-chloranyl-1~{H}-indole-2-carboxylic acid | non-polymer | 495.9 | 1 | Chemie (B5K) | |||
3 | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A: 18 - 113 (UniProt: Q00987)
PDB | External Database | Details |
---|---|---|
Met 17 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 11399.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 495.9 | |
All* | Total formula weight | 11895.3 |