2AXI
HDM2 in complex with a beta-hairpin
Summary for 2AXI
Entry DOI | 10.2210/pdb2axi/pdb |
Related PRD ID | PRD_000326 |
Descriptor | Ubiquitin-protein ligase E3 Mdm2, cyclic 8-mer peptide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | p53, drug design, protein-protein interactions, ligase, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 15165.55 |
Authors | Mittl, P.R.E.,Fasan, R.,Robinson, J.,Gruetter, M.G. (deposition date: 2005-09-05, release date: 2006-03-21, Last modification date: 2023-08-23) |
Primary citation | Fasan, R.,Dias, R.L.,Moehle, K.,Zerbe, O.,Obrecht, D.,Mittl, P.R.,Robinson, J.A. Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction. Chembiochem, 7:515-526, 2006 Cited by PubMed: 16511824DOI: 10.1002/cbic.200500452 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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