7QDQ

Crystal Structure of HDM2 in complex with Caylin-1

Summary for 7QDQ

Entry DOI	10.2210/pdb7qdq/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, CHLORIDE ION, SODIUM ION, ... (7 entities in total)
Functional Keywords	nmr molecular replacement, complex structure, drug design, nmr spectroscopy, structure elucidation, ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	11825.68
Authors	Finke, A.D.,Walti, M.A.,Marsh, M.E.,Orts, J. (deposition date: 2021-11-29, release date: 2022-10-05, Last modification date: 2024-02-07)
Primary citation	Mertens, V.,Abi Saad, M.J.,Coudevylle, N.,Walti, M.A.,Finke, A.,Marsh, M.,Orts, J. Elucidation of a nutlin-derivative-HDM2 complex structure at the interaction site by NMR molecular replacement: A straightforward derivation J Magn Reson Open, 10-11:100032-, 2022 Cited by DOI: 10.1016/j.jmro.2022.100032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.26 Å)

Structure validation