NMR Structure of Mdm2 (6-125) with Pip-1

Summary for 2LZG

DescriptorE3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid (2 entities in total)
Functional Keywordsmdm2, oncogene protein-inhibitor complex, protein binding
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm Q00987
Total number of polymer chains1
Total molecular weight14591.52
Primary citation
Michelsen, K.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L.
Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
J.Am.Chem.Soc., 134:17059-17067, 2012
PubMed: 22991965 (PDB entries with the same primary citation)
DOI: 10.1021/ja305839b
MImport into Mendeley
Experimental method
NMR Information

Structure validation

ClashscoreRamachandran outliersSidechain outliers02.1%17.9%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

Molmil generated image of 2lzg
no rotation
Molmil generated image of 2lzg
rotated about x axis by 90°
Molmil generated image of 2lzg
rotated about y axis by 90°