6GGN

In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor

Summary for 6GGN

Entry DOI	10.2210/pdb6ggn/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, (4~{S})-4-(4-chloranyl-2-methyl-phenyl)-5-(5-chloranyl-2-methyl-phenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-3-propan-2-yl-4~{H}-pyrrolo[3,4-d]imidazol-6-one, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	ppi with p53, inhibitor complex, cell cycle
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	11743.96
Authors	Kallen, J. (deposition date: 2018-05-03, release date: 2018-09-26, Last modification date: 2024-01-17)
Primary citation	Vaupel, A.,Holzer, P.,Ferretti, S.,Guagnano, V.,Kallen, J.,Mah, R.,Masuya, K.,Ruetz, S.,Rynn, C.,Schlapbach, A.,Stachyra, T.,Stutz, S.,Todorov, M.,Jeay, S.,Furet, P. In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor. Bioorg. Med. Chem. Lett., 28:3404-3408, 2018 Cited by PubMed: 30217415 DOI: 10.1016/j.bmcl.2018.08.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation