6Y4Q

Structure of a stapled peptide bound to MDM2

Summary for 6Y4Q

Entry DOI	10.2210/pdb6y4q/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, ACE-LEU-THR-PHE-GLY-GLU-TYR-TRP-ALA-GLN-LEU-ALA-SER, ~{N}-[(1-ethyl-1,2,3-triazol-4-yl)methyl]-~{N},5-dimethyl-4-[2-[2-methyl-5-[methyl-[(1-propyl-1,2,3-triazol-4-yl)methyl]carbamoyl]thiophen-3-yl]cyclopenten-1-yl]thiophene-2-carboxamide, ... (4 entities in total)
Functional Keywords	mdm2, p53, stapled, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	25377.72
Authors	Pantelejevs, T.,Bakanovych, I. (deposition date: 2020-02-22, release date: 2020-05-20, Last modification date: 2024-01-24)
Primary citation	Strizhak, A.V.,Babii, O.,Afonin, S.,Bakanovich, I.,Pantelejevs, T.,Xu, W.,Fowler, E.,Eapen, R.,Sharma, K.,Platonov, M.O.,Hurmach, V.V.,Itzhaki, L.,Hyvonen, M.,Ulrich, A.S.,Spring, D.R.,Komarov, I.V. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. Org.Biomol.Chem., 18:5359-5369, 2020 Cited by PubMed: 32390036 DOI: 10.1039/d0ob00831a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.63 Å)

Structure validation