6Y4Q

Structure of a stapled peptide bound to MDM2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for Di-peptide ACE C 0 and LEU C 1

Chain	Residue
A	PRO32
A	LYS36
A	GLN72
A	HOH222
C	THR2
C	GLU5
C	TYR6

---

site_id	AC2
Number of Residues	16
Details	binding site for Di-peptide O9E C 1001 and GLY C 4

Chain	Residue
A	GLN59
A	HOH209
B	LYS51
B	PHE55
B	ALA70
B	HOH220
C	THR2
C	PHE3
C	GLU5
C	TYR6
C	TRP7
C	ALA8
C	ALA11
D	O9E101
A	LYS51
A	PHE55

---

site_id	AC3
Number of Residues	16
Details	binding site for Di-peptide O9E C 1001 and ALA C 11

Chain	Residue
A	GLN24
A	LYS51
A	PHE55
A	GLN59
A	HOH209
B	LYS51
B	PHE55
B	ALA70
C	GLY4
C	GLU5
C	TRP7
C	ALA8
C	GLN9
C	LEU10
C	SER12
D	O9E101

---

site_id	AC4
Number of Residues	7
Details	binding site for Di-peptide ACE D 0 and LEU D 1

Chain	Residue
B	GLN72
D	THR2
D	GLU5
D	TYR6
D	GLN9
D	HOH201
D	HOH208

---

site_id	AC5
Number of Residues	15
Details	binding site for Di-peptide O9E D 101 and ALA D 11

Chain	Residue
A	LYS51
A	PHE55
B	GLN24
B	LYS51
B	PHE55
B	HOH232
C	O9E1001
D	PHE3
D	GLY4
D	GLU5
D	TRP7
D	ALA8
D	GLN9
D	LEU10
D	SER12

---

site_id	AC6
Number of Residues	14
Details	binding site for Di-peptide O9E D 101 and GLY D 4

Chain	Residue
A	LYS51
A	PHE55
B	LYS51
B	PHE55
B	HOH232
C	O9E1001
D	THR2
D	PHE3
D	GLU5
D	TYR6
D	TRP7
D	ALA8
D	ALA11
D	HOH211

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