6Y4Q
Structure of a stapled peptide bound to MDM2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase Mdm2 | polymer | 92 | 10670.5 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | C, D (C, D) | ACE-LEU-THR-PHE-GLY-GLU-TYR-TRP-ALA-GLN-LEU-ALA-SER | polymer | 13 | 1411.6 | 2 | Homo sapiens | ||
| 3 | E, F (C, D) | ~{N}-[(1-ethyl-1,2,3-triazol-4-yl)methyl]-~{N},5-dimethyl-4-[2-[2-methyl-5-[methyl-[(1-propyl-1,2,3-triazol-4-yl)methyl]carbamoyl]thiophen-3-yl]cyclopenten-1-yl]thiophene-2-carboxamide | non-polymer | 606.8 | 2 | Chemie (O9E) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 126 | Chemie (HOH) |
Sequence modifications
A, B: 17 - 108 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Ala 69 | Glu 69 | engineered mutation |
| Ala 70 | Lys 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 24164.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1213.6 | |
| All* | Total formula weight | 25377.7 |
