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5C5A

Crystal Structure of HDM2 in complex with Nutlin-3a

Summary for 5C5A
Entry DOI10.2210/pdb5c5a/pdb
DescriptorE3 ubiquitin-protein ligase Mdm2, 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, SULFATE ION, ... (6 entities in total)
Functional Keywordsdrug design, hdm2, complex structure, ligase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains2
Total formula weight23474.90
Authors
Orts, J.,Waelti, M.A.,Marsh, M.,Vera, L.,Gossert, A.D.,Guentert, P.,Riek, R. (deposition date: 2015-06-19, release date: 2016-06-29, Last modification date: 2024-01-10)
Primary citationOrts, J.,Waelti, M.A.,Marsh, M.,Vera, L.,Gossert, A.D.,Guentert, P.,Riek, R.
NMR Molecular Replacement, NMR2
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.146 Å)
Structure validation

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