5C5A
Crystal Structure of HDM2 in complex with Nutlin-3a
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | E3 ubiquitin-protein ligase Mdm2 | polymer | 92 | 10770.6 | 2 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
2 | A, B | 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one | non-polymer | 581.5 | 2 | Chemie (NUT) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
5 | A, B | IODIDE ION | non-polymer | 126.9 | 4 | Chemie (IOD) | |||
6 | water | water | 18.0 | 172 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 21541.3 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 1933.6 | |
All* | Total formula weight | 23474.9 |