5C5A

Crystal Structure of HDM2 in complex with Nutlin-3a

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue NUT A 201

Chain	Residue
A	LEU54
A	HOH335
A	HOH350
B	ARG29
A	GLY58
A	GLN59
A	MET62
A	GLN72
A	VAL93
A	HIS96
A	ILE99
A	TYR100

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 202

Chain	Residue
A	ARG105
A	HOH302
A	HOH304

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site_id	AC3
Number of Residues	2
Details	binding site for residue IOD A 204

Chain	Residue
A	THR26
A	LYS51

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site_id	AC4
Number of Residues	12
Details	binding site for residue NUT B 201

Chain	Residue
A	ARG29
B	LEU54
B	GLY58
B	GLN59
B	MET62
B	GLN72
B	VAL93
B	HIS96
B	ILE99
B	TYR100
B	HOH332
B	HOH347

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site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 B 202

Chain	Residue
B	SER22
B	GLU23
B	GLN24
B	LYS70
B	HOH304
B	HOH320
B	HOH329

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site_id	AC6
Number of Residues	2
Details	binding site for residue IOD B 204

Chain	Residue
B	THR26
B	LYS51

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site_id	AC7
Number of Residues	1
Details	binding site for residue IOD B 205

Chain	Residue
A	LEU33

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site_id	AC8
Number of Residues	1
Details	binding site for residue IOD B 206

Chain	Residue
B	LEU33

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