2R53
| |
2R52
| |
2TGI
| |
2V5E
| The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding. | Descriptor: | 1,2-ETHANEDIOL, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Parkash, V, Leppanen, V.-M, Virtanen, H, Jurvansuu, J.-M, Bespalov, M.M, Sidorova, Y.A, Runeberg-Roos, P, Saarma, M, Goldman, A. | Deposit date: | 2008-10-03 | Release date: | 2008-10-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding. J.Biol.Chem., 283, 2008
|
|
4UX8
| RET recognition of GDNF-GFRalpha1 ligand by a composite binding site promotes membrane-proximal self-association | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF FAMILY RECEPTOR ALPHA-1, ... | Authors: | Goodman, K, Kjaer, S, Beuron, F, Knowles, P, Nawrotek, A, Burns, E, Purkiss, A, George, R, Santoro, M, Morris, E.P, McDonald, N.Q. | Deposit date: | 2014-08-19 | Release date: | 2014-10-01 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (24 Å) | Cite: | Ret Recognition of Gdnf-Gfralpha1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association. Cell Rep., 8, 2014
|
|
4FAO
| Specificity and Structure of a high affinity Activin-like 1 (ALK1) signaling complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B, Growth/differentiation factor 2, ... | Authors: | Townson, S.A, Martinez-Hackert, E, Greppi, C, Lowden, P, Sako, D, Liu, J, Ucran, J.A, Liharska, K, Underwood, K.W, Seehra, J, Kumar, R, Grinberg, A.V. | Deposit date: | 2012-05-22 | Release date: | 2012-06-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.357 Å) | Cite: | Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex. J.Biol.Chem., 287, 2012
|
|
3SEK
| Crystal Structure of the Myostatin:Follistatin-like 3 Complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Follistatin-related protein 3, Growth/differentiation factor 8 | Authors: | Cash, J.N, Thompson, T.B. | Deposit date: | 2011-06-10 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.401 Å) | Cite: | Structure of myostatinfollistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. J.Biol.Chem., 287, 2012
|
|
8OS6
| Structure of a GFRA1/GDNF LICAM complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Houghton, F.M, Adams, S.E, Briggs, D.C, McDonald, N.Q. | Deposit date: | 2023-04-18 | Release date: | 2023-11-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Architecture and regulation of a GDNF-GFR alpha 1 synaptic adhesion assembly. Nat Commun, 14, 2023
|
|
1ES7
| |
6UJA
| Integrin alpha-v beta-8 in complex with pro-TGF-beta1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Campbell, M.G, Cormier, A, Cheng, Y, Nishimura, S.L. | Deposit date: | 2019-10-02 | Release date: | 2020-02-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180, 2020
|
|
6UMX
| Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015 | Descriptor: | GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain, GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain, GLYCEROL, ... | Authors: | Dagbay, K.B, Treece, E, Streich Jr, F.C, Jackson, J.W, Faucette, R.R, Nikiforov, A, Lin, S.C, Bostion, C.J, Nicholls, S.B, Capili, A.D, Carven, G.J. | Deposit date: | 2019-10-10 | Release date: | 2020-02-26 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.79 Å) | Cite: | Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015. J.Biol.Chem., 295, 2020
|
|
7AML
| RET/GDNF/GFRa1 extracellular complex Cryo-EM structure | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GDNF family receptor alpha, ... | Authors: | Adams, S.E, Earl, C.P, Purkiss, A.G, McDonald, N.Q. | Deposit date: | 2020-10-09 | Release date: | 2021-01-13 | Last modified: | 2021-07-14 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing. Structure, 29, 2021
|
|
5NTU
| Crystal Structure of human Pro-myostatin Precursor at 2.6 A Resolution | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Growth/differentiation factor 8 | Authors: | Cotton, T.R, Fischer, G, Hyvonen, M. | Deposit date: | 2017-04-28 | Release date: | 2018-01-17 | Last modified: | 2018-02-21 | Method: | X-RAY DIFFRACTION (2.58 Å) | Cite: | Structure of the human myostatin precursor and determinants of growth factor latency. EMBO J., 37, 2018
|
|
5NXS
| |
7AG0
| Complex between the bone morphogenetic protein 2 and its antagonist Noggin | Descriptor: | Bone morphogenetic protein 2, GLYCEROL, Noggin | Authors: | Robert, C, Bruck, F, Herman, R, Vandevenne, M, Filee, P, Kerff, F, Matagne, A. | Deposit date: | 2020-09-21 | Release date: | 2022-04-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.104 Å) | Cite: | Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition. J.Biol.Chem., 299, 2023
|
|
7MRZ
| Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2B,Activin receptor type-1B, Fab Heavy Chain, ... | Authors: | Goebel, E.J, Kattamuri, C, Gipson, G.R, Thompson, T.B. | Deposit date: | 2021-05-10 | Release date: | 2022-01-19 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25, 2022
|
|
4YCG
| Pro-bone morphogenetic protein 9 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone Morphogenetic Protein 9 Growth Factor Domain, Bone Morphogenetic Protein 9 Prodomain, ... | Authors: | Mi, L.-Z, Brown, C.T, Gao, Y, Tian, Y, Le, V, Walz, T, Springer, T.A. | Deposit date: | 2015-02-20 | Release date: | 2015-03-04 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structure of bone morphogenetic protein 9 procomplex. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
8FXV
| Crystal structure of human proTGF-beta2 in complex with Nb18 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody clone 18, Transforming growth factor beta-2 proprotein | Authors: | Le, V.Q, Springer, T.A. | Deposit date: | 2023-01-25 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8FXS
| Crystal structure of human pro-TGF-beta2 in complex with Nb9 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody clone 9, Transforming growth factor beta-2 proprotein | Authors: | Le, V.Q, Springer, T.A. | Deposit date: | 2023-01-25 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8. Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
7U5O
| CRYSTAL STRUCTURE OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE 2 LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-B | Descriptor: | Bone morphogenetic protein receptor type-2, Inhibin beta B chain | Authors: | Chu, K.Y, Malik, A, Thamilselvan, V, Martinez-Hackert, E. | Deposit date: | 2022-03-02 | Release date: | 2022-06-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. J.Biol.Chem., 298, 2022
|
|
7U5P
| CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-2A, Inhibin beta A chain | Authors: | Chu, K.Y, Malik, A, Thamilselvan, V, Martinez-Hackert, E. | Deposit date: | 2022-03-02 | Release date: | 2022-06-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.14 Å) | Cite: | Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. J.Biol.Chem., 298, 2022
|
|
4YCI
| non-latent pro-bone morphogenetic protein 9 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bone Morphogenetic Protein 9 Growth Factor Domain, ... | Authors: | Mi, L.Z, Brown, C.T, Gao, Y, Tian, Y, Le, V, Walz, T, Springer, T.A. | Deposit date: | 2015-02-20 | Release date: | 2015-03-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Structure of bone morphogenetic protein 9 procomplex. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
7OLY
| Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Activin receptor type-1B, ... | Authors: | Hakansson, M, Rose, N.C, Castonguay, R, Logan, D.T, Krishnan, L. | Deposit date: | 2021-05-20 | Release date: | 2022-02-23 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.265 Å) | Cite: | Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25, 2022
|
|
6GFF
| Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Leucine-rich repeat-containing protein 32, MHG-8 Fab heavy chain, ... | Authors: | Merceron, R, Lienart, S, Vanderaa, C, Colau, D, Stockis, J, Van Der Woning, B, De Haard, H, Saunders, M, Coulie, P.G, Savvides, S.N, Lucas, S. | Deposit date: | 2018-04-30 | Release date: | 2018-11-07 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells. Science, 362, 2018
|
|
6GL7
| Neurturin-GFRa2-RET extracellular complex | Descriptor: | GDNF family receptor alpha-2, Neurturin, Proto-oncogene tyrosine-protein kinase receptor Ret | Authors: | Bigalke, J.M, Aibara, S, Sandmark, J, Amunts, A. | Deposit date: | 2018-05-23 | Release date: | 2019-08-14 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (6.3 Å) | Cite: | Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain. Sci Adv, 5, 2019
|
|