6GFF

Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab

Summary for 6GFF

DescriptorTransforming growth factor beta-1, Leucine-rich repeat-containing protein 32, MHG-8 Fab light chain, ... (8 entities in total)
Functional Keywordsgarp, tgf-b1, activation, treg, immune system
Biological sourceHomo sapiens (Human)
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Total number of polymer chains14
Total molecular weight398613.13
Authors
Primary citation
Lienart, S.,Merceron, R.,Vanderaa, C.,Lambert, F.,Colau, D.,Stockis, J.,van der Woning, B.,De Haard, H.,Saunders, M.,Coulie, P.G.,Savvides, S.N.,Lucas, S.
Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells.
Science, 2018
PubMed: 30361387 (PDB entries with the same primary citation)
DOI: 10.1126/science.aau2909
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27150 0.4% 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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Molmil generated image of 6gff
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6gff.pdb1.gz [494.99 KB])
Coordinate files for Biological unit (6gff.pdb2.gz [448.41 KB])
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