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6GFF

Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab

Summary for 6GFF
Entry DOI10.2210/pdb6gff/pdb
DescriptorTransforming growth factor beta-1, Leucine-rich repeat-containing protein 32, MHG-8 Fab light chain, ... (8 entities in total)
Functional Keywordsgarp, tgf-b1, activation, treg, immune system
Biological sourceHomo sapiens (Human)
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Total number of polymer chains14
Total formula weight398360.92
Authors
Merceron, R.,Lienart, S.,Vanderaa, C.,Colau, D.,Stockis, J.,Van Der Woning, B.,De Haard, H.,Saunders, M.,Coulie, P.G.,Savvides, S.N.,Lucas, S. (deposition date: 2018-04-30, release date: 2018-11-07, Last modification date: 2020-07-29)
Primary citationLienart, S.,Merceron, R.,Vanderaa, C.,Lambert, F.,Colau, D.,Stockis, J.,van der Woning, B.,De Haard, H.,Saunders, M.,Coulie, P.G.,Savvides, S.N.,Lucas, S.
Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells.
Science, 362:952-956, 2018
Cited by
PubMed: 30361387
DOI: 10.1126/science.aau2909
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.1 Å)
Structure validation

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