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6GFF

Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab

Functional Information from GO Data
ChainGOidnamespacecontents
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
B0005576cellular_componentextracellular region
B0008083molecular_functiongrowth factor activity
C0005160molecular_functiontransforming growth factor beta receptor binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
D0005576cellular_componentextracellular region
D0008083molecular_functiongrowth factor activity
E0005160molecular_functiontransforming growth factor beta receptor binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
F0005576cellular_componentextracellular region
F0008083molecular_functiongrowth factor activity
G0005160molecular_functiontransforming growth factor beta receptor binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
H0005576cellular_componentextracellular region
H0008083molecular_functiongrowth factor activity
I0001818biological_processnegative regulation of cytokine production
I0005515molecular_functionprotein binding
I0005615cellular_componentextracellular space
I0005654cellular_componentnucleoplasm
I0005886cellular_componentplasma membrane
I0007179biological_processtransforming growth factor beta receptor signaling pathway
I0009897cellular_componentexternal side of plasma membrane
I0009986cellular_componentcell surface
I0010628biological_processpositive regulation of gene expression
I0016020cellular_componentmembrane
I0019838molecular_functiongrowth factor binding
I0031012cellular_componentextracellular matrix
I0046007biological_processnegative regulation of activated T cell proliferation
I0050431molecular_functiontransforming growth factor beta binding
I0062009biological_processsecondary palate development
I1901388biological_processobsolete regulation of transforming growth factor beta activation
I1901398biological_processobsolete regulation of transforming growth factor beta3 activation
J0001818biological_processnegative regulation of cytokine production
J0005515molecular_functionprotein binding
J0005615cellular_componentextracellular space
J0005654cellular_componentnucleoplasm
J0005886cellular_componentplasma membrane
J0007179biological_processtransforming growth factor beta receptor signaling pathway
J0009897cellular_componentexternal side of plasma membrane
J0009986cellular_componentcell surface
J0010628biological_processpositive regulation of gene expression
J0016020cellular_componentmembrane
J0019838molecular_functiongrowth factor binding
J0031012cellular_componentextracellular matrix
J0046007biological_processnegative regulation of activated T cell proliferation
J0050431molecular_functiontransforming growth factor beta binding
J0062009biological_processsecondary palate development
J1901388biological_processobsolete regulation of transforming growth factor beta activation
J1901398biological_processobsolete regulation of transforming growth factor beta3 activation
Functional Information from PROSITE/UniProt
site_idPS00250
Number of Residues16
DetailsTGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC
ChainResidueDetails
BILE311-CYS326

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
KTYR212-HIS218

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1214
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
IHIS20-ASN627
JHIS20-ASN627
EARG278
GARG278

site_idSWS_FT_FI2
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
IASN203
IASN271
IASN345
IASN545
JASN203
JASN271
JASN345
JASN545

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
IASN308
JASN308
CASN136
CASN176
EASN136
EASN176
GASN136
GASN176

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PDB entries from 2024-04-17

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