Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6GFF

Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005160	molecular_function	transforming growth factor beta receptor binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
B	0005576	cellular_component	extracellular region
B	0008083	molecular_function	growth factor activity
C	0005160	molecular_function	transforming growth factor beta receptor binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
D	0005576	cellular_component	extracellular region
D	0008083	molecular_function	growth factor activity
E	0005160	molecular_function	transforming growth factor beta receptor binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
F	0005576	cellular_component	extracellular region
F	0008083	molecular_function	growth factor activity
G	0005160	molecular_function	transforming growth factor beta receptor binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
H	0005576	cellular_component	extracellular region
H	0008083	molecular_function	growth factor activity
I	0005515	molecular_function	protein binding
I	0005654	cellular_component	nucleoplasm
I	0005886	cellular_component	plasma membrane
I	0007179	biological_process	transforming growth factor beta receptor signaling pathway
I	0009986	cellular_component	cell surface
I	0019838	molecular_function	growth factor binding
I	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
I	0035592	biological_process	establishment of protein localization to extracellular region
I	0038023	molecular_function	signaling receptor activity
I	0050431	molecular_function	transforming growth factor beta binding
I	0062009	biological_process	secondary palate development
I	0141069	molecular_function	receptor ligand inhibitor activity
J	0005515	molecular_function	protein binding
J	0005654	cellular_component	nucleoplasm
J	0005886	cellular_component	plasma membrane
J	0007179	biological_process	transforming growth factor beta receptor signaling pathway
J	0009986	cellular_component	cell surface
J	0019838	molecular_function	growth factor binding
J	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
J	0035592	biological_process	establishment of protein localization to extracellular region
J	0038023	molecular_function	signaling receptor activity
J	0050431	molecular_function	transforming growth factor beta binding
J	0062009	biological_process	secondary palate development
J	0141069	molecular_function	receptor ligand inhibitor activity

Functional Information from PROSITE/UniProt

site_id	PS00250
Number of Residues	16
Details	TGF_BETA_1 TGF-beta family signature. IhePkgYhanfClGpC

Chain	Residue	Details
B	ILE311-CYS326

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
K	TYR212-HIS218

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Region: {"description":"Straightjacket domain","evidences":[{"source":"UniProtKB","id":"P07200","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28117447","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FFO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	15
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	54
Details	Domain: {"description":"LRRNT","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	46
Details	Repeat: {"description":"LRR 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	42
Details	Repeat: {"description":"LRR 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	42
Details	Repeat: {"description":"LRR 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	40
Details	Repeat: {"description":"LRR 4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	42
Details	Repeat: {"description":"LRR 5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	42
Details	Repeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	42
Details	Repeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	40
Details	Repeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	42
Details	Repeat: {"description":"LRR 9","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	46
Details	Repeat: {"description":"LRR 11","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	46
Details	Repeat: {"description":"LRR 12","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	42
Details	Repeat: {"description":"LRR 13","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	42
Details	Repeat: {"description":"LRR 14","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	21
Details	Repeat: {"description":"LRR 15","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	42
Details	Repeat: {"description":"LRR 16","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	42
Details	Repeat: {"description":"LRR 17","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	42
Details	Repeat: {"description":"LRR 18","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	42
Details	Repeat: {"description":"LRR 19","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	21
Details	Repeat: {"description":"LRR 20","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)