7OLY

Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions

Summary for 7OLY

Entry DOI	10.2210/pdb7oly/pdb
Descriptor	Inhibin beta A chain, Activin receptor type-2B, Fab heavy chain, ... (8 entities in total)
Functional Keywords	growth factor, receptor, tgfb, signaling, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	90359.90
Authors	Hakansson, M.,Rose, N.C.,Castonguay, R.,Logan, D.T.,Krishnan, L. (deposition date: 2021-05-20, release date: 2022-02-23, Last modification date: 2024-01-31)
Primary citation	Goebel, E.J.,Kattamuri, C.,Gipson, G.R.,Krishnan, L.,Chavez, M.,Czepnik, M.,Maguire, M.C.,Grenha, R.,Hakansson, M.,Logan, D.T.,Grinberg, A.V.,Sako, D.,Castonguay, R.,Kumar, R.,Thompson, T.B. Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors. Iscience, 25:103590-103590, 2022 Cited by PubMed: 35005539 DOI: 10.1016/j.isci.2021.103590 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.265 Å)

Structure validation