7OLY
Structure of activin A in complex with an ActRIIB-Alk4 fusion reveal insight into activin receptor interactions
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Inhibin beta A chain | polymer | 116 | 12991.9 | 1 | UniProt (P08476) Pfam (PF00019) | Homo sapiens (Human) | Activin beta-A chain,Erythroid differentiation protein,EDF |
| 2 | B (C) | Activin receptor type-2B | polymer | 133 | 14933.4 | 1 | UniProt (Q13705) Pfam (PF01064) | Homo sapiens (Human) | Activin receptor type IIB,ACTR-IIB |
| 3 | C (H) | Fab heavy chain | polymer | 225 | 23772.6 | 1 | Homo sapiens (Human) | ||
| 4 | D (K) | Activin receptor type-1B | polymer | 121 | 13123.0 | 1 | UniProt (P36896) Pfam (PF01064) | Homo sapiens (Human) | Activin receptor type IB,ACTR-IB,Activin receptor-like kinase 4,ALK-4,Serine/threonine-protein kinase receptor R2,SKR2 |
| 5 | E (L) | Fab light chain | polymer | 221 | 24203.9 | 1 | Homo sapiens (Human) | ||
| 6 | F (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 1 | In PDB | |||
| 7 | G (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 8 | H, I, J (C, H, L) | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
C: 19 - 134 (UniProt: Q13705)
K: 24 - 126 (UniProt: P36896)
| PDB | External Database | Details |
|---|---|---|
| Gly 135 | - | linker |
| Gly 136 | - | linker |
| Gly 137 | - | linker |
| Thr 138 | - | linker |
| His 139 | - | linker |
| Thr 140 | - | linker |
| Cys 141 | - | linker |
| Pro 142 | - | linker |
| Pro 143 | - | linker |
| Cys 144 | - | linker |
| Pro 145 | - | linker |
| Ala 146 | - | linker |
| Pro 147 | - | linker |
| Glu 148 | - | linker |
| Leu 149 | - | linker |
| Leu 150 | - | linker |
| Gly 151 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Thr 127 | - | linker |
| Gly 128 | - | linker |
| Gly 129 | - | linker |
| Gly 130 | - | linker |
| Thr 131 | - | linker |
| His 132 | - | linker |
| Thr 133 | - | linker |
| Cys 134 | - | linker |
| Pro 135 | - | linker |
| Pro 136 | - | linker |
| Cys 137 | - | linker |
| Pro 138 | - | linker |
| Ala 139 | - | linker |
| Pro 140 | - | linker |
| Glu 141 | - | linker |
| Leu 142 | - | linker |
| Leu 143 | - | linker |
| Gly 144 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 89024.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1114.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 90359.9 |
