2V5E

The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding.

Summary for 2V5E

• Entry DOI: 10.2210/pdb2v5e/pdb
• Related: 1AGQ
• Related PRD ID: PRD_900013
• Descriptor: GDNF FAMILY RECEPTOR ALPHA-1, GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: receptor-glycoprotein complex, alternative splicing, cell membrane, growth factor, ligand-coreceptor, gpi-anchor, lipoprotein, polymorphism, glycoprotein, membrane, receptor, secreted, gfralpha1, cleavage on pair of basic residues, receptor-glycoprotein complex complex, receptor/glycoprotein complex
• Biological source: RATTUS NORVEGICUS (NORWAY RAT); More
• Total number of polymer chains: 2
• Total formula weight: 35421.03

Authors

Parkash, V.,Leppanen, V.-M.,Virtanen, H.,Jurvansuu, J.-M.,Bespalov, M.M.,Sidorova, Y.A.,Runeberg-Roos, P.,Saarma, M.,Goldman, A. (deposition date: 2008-10-03, release date: 2008-10-21, Last modification date: 2023-12-13)

• Primary citation: Parkash, V.,Leppanen, V.-M.,Virtanen, H.,Jurvansuu, J.-M.,Bespalov, M.M.,Sidorova, Y.A.,Runeberg-Roos, P.,Saarma, M.,Goldman, A.; The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding.; J.Biol.Chem., 283:35164-, 2008; PubMed: 18845535; DOI: 10.1074/JBC.M802543200

Experimental method

X-RAY DIFFRACTION (2.35 Å)