Crystal Structure of the Myostatin:Follistatin-like 3 Complex

Summary for 3SEK

DescriptorGrowth/differentiation factor 8, Follistatin-related protein 3, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywordsprotein-protein complex, tb domain, cystine knot motif, tgf-beta fold, disulfide linked dimer, follistatin domain (fsd), signaling protein
Biological sourceMus musculus (mouse)
Total number of polymer chains2
Total molecular weight34876.97
Cash, J.N.,Thompson, T.B. (deposition date: 2011-06-10, release date: 2011-11-02, Last modification date: 2020-07-29)
Primary citation
Cash, J.N.,Angerman, E.B.,Kattamuri, C.,Nolan, K.,Zhao, H.,Sidis, Y.,Keutmann, H.T.,Thompson, T.B.
Structure of myostatinfollistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding.
J.Biol.Chem., 287:1043-1053, 2012
PubMed: 22052913 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M111.270801
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26130 1.6% 4.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-12-02