7MRZ

Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment

Summary for 7MRZ

• Entry DOI: 10.2210/pdb7mrz/pdb
• Descriptor: Growth/differentiation factor 11, Activin receptor type-2B,Activin receptor type-1B, Fab Heavy Chain, ... (6 entities in total)
• Functional Keywords: growth factor, type i receptor, transforming growth factor beta, type ii receptor, ternary complex, gdf11, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 88371.92

Authors

Goebel, E.J.,Kattamuri, C.,Gipson, G.R.,Thompson, T.B. (deposition date: 2021-05-10, release date: 2022-01-19, Last modification date: 2023-10-18)

• Primary citation: Goebel, E.J.,Kattamuri, C.,Gipson, G.R.,Krishnan, L.,Chavez, M.,Czepnik, M.,Maguire, M.C.,Grenha, R.,Hakansson, M.,Logan, D.T.,Grinberg, A.V.,Sako, D.,Castonguay, R.,Kumar, R.,Thompson, T.B.; Structures of activin ligand traps using natural sets of type I and type II TGF beta receptors.; Iscience, 25:103590-103590, 2022; PubMed: 35005539; DOI: 10.1016/j.isci.2021.103590

Experimental method

X-RAY DIFFRACTION (3 Å)