7MRZ
Structure of GDF11 bound to fused ActRIIB-ECD and Alk4-ECD with Anti-ActRIIB Fab fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Growth/differentiation factor 11 | polymer | 109 | 12471.3 | 1 | UniProt (O95390) Pfam (PF00019) In PDB | Homo sapiens (human) | GDF-11,Bone morphogenetic protein 11,BMP-11 |
| 2 | C | Activin receptor type-2B,Activin receptor type-1B | polymer | 254 | 27952.3 | 1 | UniProt (Q13705) UniProt (P36896) Pfam (PF01064) In PDB | Homo sapiens (human) | ACTR-IIB fused to Activin receptor-like kinase 4 |
| 3 | X | Fab Heavy Chain | polymer | 222 | 23427.2 | 1 | Homo sapiens | ||
| 4 | Y | Fab Light Chain | polymer | 221 | 24203.9 | 1 | Homo sapiens | ||
| 5 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | X | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) |
Sequence modifications
C: 19 - 134 (UniProt: Q13705)
C: 1024 - 1126 (UniProt: P36896)
| PDB | External Database | Details |
|---|---|---|
| Gly 1007 | - | linker |
| Gly 1008 | - | linker |
| Gly 1009 | - | linker |
| Thr 1010 | - | linker |
| His 1011 | - | linker |
| Thr 1012 | - | linker |
| Cys 1013 | - | linker |
| Pro 1014 | - | linker |
| Pro 1015 | - | linker |
| Cys 1016 | - | linker |
| Pro 1017 | - | linker |
| Ala 1018 | - | linker |
| Pro 1019 | - | linker |
| Glu 1020 | - | linker |
| Leu 1021 | - | linker |
| Leu 1022 | - | linker |
| Gly 1023 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 1067 | Arg 67 | conflict |
| Thr 1127 | - | expression tag |
| Gly 1128 | - | expression tag |
| Gly 1129 | - | expression tag |
| Gly 1130 | - | expression tag |
| Thr 1131 | - | expression tag |
| His 1132 | - | expression tag |
| Thr 1133 | - | expression tag |
| Cys 1134 | - | expression tag |
| Pro 1135 | - | expression tag |
| Pro 1136 | - | expression tag |
| Cys 1137 | - | expression tag |
| Pro 1138 | - | expression tag |
| Ala 1139 | - | expression tag |
| Pro 1140 | - | expression tag |
| Glu 1141 | - | expression tag |
| Leu 1142 | - | expression tag |
| Leu 1143 | - | expression tag |
| Gly 1144 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 88054.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 317.3 | |
| All* | Total formula weight | 88371.9 |
