6UMX

Structural basis for specific inhibition of extracellular activation of pro/latent myostatin by SRK-015

Summary for 6UMX

Entry DOI	10.2210/pdb6umx/pdb
Descriptor	Growth/differentiation factor 8, GL29H4-16 Fab Light Chain,GL29H4-16 Fab Light Chain, GL29H4-16 Fab Heavy Chain,GL29H4-16 Fab Heavy Chain, ... (5 entities in total)
Functional Keywords	myostatin, gdf8, transforming growth factor beta, muscle wasting disease, antibody, fab, signaling protein-immune system complex, signaling protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	178140.31
Authors	Dagbay, K.B.,Treece, E.,Streich Jr., F.C.,Jackson, J.W.,Faucette, R.R.,Nikiforov, A.,Lin, S.C.,Bostion, C.J.,Nicholls, S.B.,Capili, A.D.,Carven, G.J. (deposition date: 2019-10-10, release date: 2020-02-26, Last modification date: 2023-10-11)
Primary citation	Dagbay, K.B.,Treece, E.,Streich Jr., F.C.,Jackson, J.W.,Faucette, R.R.,Nikiforov, A.,Lin, S.C.,Boston, C.J.,Nicholls, S.B.,Capili, A.D.,Carven, G.J. Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015. J.Biol.Chem., 295:5404-5418, 2020 Cited by PubMed: 32075906 DOI: 10.1074/jbc.RA119.012293 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.79 Å)

Structure validation