7AML

RET/GDNF/GFRa1 extracellular complex Cryo-EM structure

Summary for 7AML

Entry DOI	10.2210/pdb7aml/pdb
Related	7AB8 7AMK
EMDB information	11822
Descriptor	Proto-oncogene tyrosine-protein kinase receptor Ret, GDNF family receptor alpha, Glial cell line-derived neurotrophic factor, ... (5 entities in total)
Functional Keywords	vertebrate development, part of the ret-gfl-gfra complex, neurotrophic factor, signaling protein
Biological source	Danio rerio (Zebrafish) More
Total number of polymer chains	6
Total formula weight	245538.29
Authors	Adams, S.E.,Earl, C.P.,Purkiss, A.G.,McDonald, N.Q. (deposition date: 2020-10-09, release date: 2021-01-13, Last modification date: 2021-07-14)
Primary citation	Adams, S.E.,Purkiss, A.G.,Knowles, P.P.,Nans, A.,Briggs, D.C.,Borg, A.,Earl, C.P.,Goodman, K.M.,Nawrotek, A.,Borg, A.J.,McIntosh, P.B.,Houghton, F.M.,Kjaer, S.,McDonald, N.Q. A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing. Structure, 29:694-, 2021 Cited by PubMed: 33484636 DOI: 10.1016/j.str.2020.12.012 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.5 Å)

Structure validation