8FXS

Crystal structure of human pro-TGF-beta2 in complex with Nb9

Summary for 8FXS

• Entry DOI: 10.2210/pdb8fxs/pdb
• Related: 8FXV
• Descriptor: Transforming growth factor beta-2 proprotein, Nanobody clone 9, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: tgf-b tgf-beta nanobody latent procomplex prodomain, cytokine
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 118437.68

Authors

Le, V.Q.,Springer, T.A. (deposition date: 2023-01-25, release date: 2023-06-21)

• Primary citation: Le, V.Q.,Zhao, B.,Ramesh, S.,Toohey, C.,DeCosta, A.,Mintseris, J.,Liu, X.,Gygi, S.,Springer, T.A.; A specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8.; Proc.Natl.Acad.Sci.USA, 120:e2304874120-e2304874120, 2023; PubMed: 37279271; DOI: 10.1073/pnas.2304874120

Experimental method

X-RAY DIFFRACTION (3.15 Å)